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Filtered Search Results
Medchemexpress LLC 5-Methyl-2- pyrimidi | 1G
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5-Methyl-2- pyrimidi | 1G
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Medchemexpress LLC (2-pyridyldithio)-PEG1-hydrazine | 111625-28-6 | MFCD22551638 | 99.3% | 187.28 g/mol | C7H9NOS2 | 250 MG
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(2-pyridyldithio)-PEG1-hydrazine is a cleavable, single-unit PEG linker used for constructing antibody-drug conjugates (ADCs). It provides a pyridyldithio cleavable moiety and a hydrazine functional group for flexible conjugation and controlled payload release.
- Cleavable pyridyldithio linker enabling disulfide-mediated payload release.
- Single-unit PEG spacer to improve solubility and reduce steric hindrance.
- Hydrazine functional handle for versatile conjugation chemistries.
- Supplied in small research-scale quantities suitable for linker development.
- Storage and stability guidance provided for refrigerated and solvent conditions.
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Medchemexpress LLC 2,6-Piperidinedione, 3-(4-bromo-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)- | 2304754-51-4 | 99.8% | C13H12BrN3O3 | 250 MG
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E3 ligase Ligand 63 is an E3 ligase ligand designed for the synthesis of CDK2 degrader 2. It functions within the ubiquitin-proteasome system, a cellular pathway exploited by PROTACs to selectively degrade target proteins.
- Designed for synthesizing CDK2 degrader 2
- Functions as an E3 ligase ligand
- Exploits the ubiquitin-proteasome system for protein degradation
- High purity of 99.8%
- Stable for extended periods under recommended storage conditions
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Medchemexpress LLC Ilaprazole sodium hydrate | 2322264-11-7 | 99.15% | 250 MG
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Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor. It irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of 6 μM in rabbit parietal cell preparation. It is used for the research of gastric ulcers and is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor.
- Orally active proton pump inhibitor
- Irreversibly inhibits H+/K+-ATPase
- Used for research of gastric ulcers
- Potent TOPK inhibitor
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Medchemexpress LLC Sodium tetrachloropalladate(II) | 13820-53-6 | 294.21 | 250 MG
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Sodium tetrachloropalladate(II) is an organic compound primarily utilized as a catalyst and a raw material in dye production. It facilitates or promotes various chemical reactions, finding extensive applications in organic synthesis and dye preparation. Additionally, it is employed for metallization, silver plating, and electroplating of circuit boards. For in vitro applications, it serves as a biochemical reagent for life science research.
- Used as a catalyst and raw material in dye production
- Facilitates and promotes various chemical reactions
- Extensive applications in organic synthesis and dye preparation
- Employed for metallization, silver plating, and electroplating of circuit boards
- Biochemical reagent for life science research
- Brown to reddish brown solid appearance
- Purity of ≥99.0%
- Molecular weight of 294.21
- Recommended storage at 4°C, sealed and away from moisture
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Medchemexpress LLC Ethyl 6-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridine-3-carbox | 503615-07-4 | MFCD18251628 | 98.6% | C22H22N4O4 | 10 G
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This product is Ethyl 6-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxylate, a chemical compound that appears as a light green to green solid. It has been tested and complies with given specifications, showing a purity of 98.6% by LCMS. This product is for research use only and has not been fully validated for medical applications.
- Appears as a light green to green solid
- Purity of 98.6% confirmed by LCMS
- Tested and complies with specifications
- Store at 4°C, protected from light
- Store in solvent at -80°C for up to 6 months or -20°C for up to 1 month, protected from light
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Medchemexpress LLC Purmorphamine | 483367-10-8 | C31H32N6O2 | 250 MG
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Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM. This compound, appearing as a white to off-white solid, has a molecular weight of 520.62 and a chemical formula of C31H32N6O2. It induces up-regulation of alkaline phosphatase activity, RUNX-2, and osteocalcin, and also induces STAT3 phosphorylation in mouse ES cell line ES14 and mesenchymal stem cell line C3H10T1/2.
- Acts as a smoothened/Smo receptor agonist
- Induces up-regulation of alkaline phosphatase activity and RUNX-2 expression
- Promotes up-regulation of osteocalcin
- Induces STAT3 phosphorylation in mouse ES cell line ES14 and mesenchymal stem cell line C3H10T1/2
- Decreases cell numbers when combined with sirolimus
- Up-regulates markers of the osteoblast phenotype in human bone marrow mesenchymal cells
- Cited in studies for various assays including CCK-8, cell counting, and in vivo efficacy
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Medchemexpress LLC Polyoxypropylene stearyl ether | 25231-21-4 | (C3H6O)nC18H38O | 250 MG
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Polyoxypropylene stearyl ether can be used as an excipient, functioning as a surfactant, softener, lubricating, wetting, plasticizing, solubilizing, and dispersing agent. Pharmaceutical excipients are inactive ingredients in pharmaceutical preparations that improve stability, solubility, and processability, and can also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs.
- Functions as a surfactant
- Acts as a softener and lubricating agent
- Used for wetting and plasticizing
- Aids in solubilizing and dispersing
- Improves stability and solubility in pharmaceutical preparations
- Enhances processability of formulations
- Influences drug absorption, distribution, metabolism, and elimination
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Medchemexpress LLC 3-(2-Chloropyrimidin-4-yl)-1-methylindole | 1032452-86-0 | 99.47% | C13H10ClN3 | 500 G
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This compound serves as a versatile chemical intermediate crucial for the synthesis of a broad spectrum of active compounds. Its key feature lies in its fundamental role in chemical reactions, enabling the creation of complex molecules required in various research and development efforts. Researchers benefit from its high purity, ensuring consistent and reliable results in synthetic pathways.
- Essential chemical building block.
- Facilitates the synthesis of diverse active compounds.
- High purity for consistent research outcomes.
- Supports advanced chemical synthesis and drug discovery.
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Medchemexpress LLC Gw4869 | 6823-69-4 | 98.9% | 577.50 | 250 MG
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GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor with an IC50 of 1 μM. It also acts as an inhibitor of exosome biogenesis and release. This product is intended for research use only.
- Noncompetitive neutral sphingomyelinase (N-SMase) inhibitor
- Inhibits exosome biogenesis and release
- Partially inhibits TNF-induced sphingomyelin (SM) hydrolysis
- Protects from cell death in a dose-dependent manner
- Reduces pro-inflammatory cytokine production in macrophages
- Blocks ceramide-mediated inward budding of multivesicular bodies (MVBs)
- In vivo, inhibits exosome release and mitigates LPS-caused myocardial dysfunction
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Medchemexpress LLC Methyl 5-hydroxypyridine-2-carboxylate | 30766-12-2 | 153.14 | 1 ML
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Methyl 5-hydroxypyridine-2-carboxylate | 30766-12-2 | 153.14 | 1 ML
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![eMolecules ChemScene / Methyl 5-methylpyrazolo[15-a]pyridine-3-carboxylate / 100mg / 569146020 / CS-0102827 / 0.000 / 1167055-25-5 / MFCD12405119 / 190.202 / C10H10N2O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502449735.PNG-250.jpg)
eMolecules ChemScene / Methyl 5-methylpyrazolo[15-a]pyridine-3-carboxylate / 100mg / 569146020 / CS-0102827 / 0.000 / 1167055-25-5 / MFCD12405119 / 190.202 / C10H10N2O2
ChemScene / Methyl 5-methylpyrazolo[15-a]pyridine-3-carboxylate / 100mg / 569146020 / CS-0102827 / 0.000 / 1167055-25-5 / MFCD12405119 / 190.202 / C10H10N2O2
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Medchemexpress LLC 5-Methyl-2- pyrimidi | 500MG
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5-Methyl-2- pyrimidi | 500MG
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Medchemexpress LLC H4 receptor antagonist 1 | 848217-00-5 | 99.7% | 316.79 | 50 MG
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H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM. It is for research use only and not sold to patients.
- Potent and selective histamine H4 receptor inverse agonist
- IC50 of 19 nM for the H4 receptor
- Very low metabolic stability in rat microsomes, with only 1% parent compound remaining after 10 min incubation
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Medchemexpress LLC 5-Methyl-2- pyrimidi | 250MG
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5-Methyl-2- pyrimidi | 250MG
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